Professor McCaddon is a Principal General Practitioner and visiting Professor at Chester University's Biological Science Department

His work in the discovery of a mutation in the Amyloid Precursor Protein gene led to his key observation of low levels of vitamin B12 and folate in these patients

In 1992 he described how such deficiencies contribute to impaired cognition.  He predicted that such patients would have elevated blood levels of homocysteine.  This was confirmed by his research team in 1998.   Elevated blood levels of homocysteine are now a recognised risk factor for dementia

Professor McCaddon is also an Honorary Senior Research Fellow in the School of Medicine, Cardiff University.  His MD with Distinction was awarded by Sheffield University for his thesis 'Vitamin B12 deficiency and Alzheimer's disease' and he was recently awarded the 2010 William Farr Medal by the Worshipful Society of Apothecaries for his significant contribution to research concerning the care of elderly patients

His description of oxidative-stress  and single carbon metabolism form the basis of COBALZ's Platform Technology